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Author

Shilpa S. Dhar

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Open access Aug 2026

Pharmacologic Inhibition of SOX9-CDK4 by CYD-4-61 Impairs Gastric Adenocarcinoma Growth and Amplifies Anti-PD-1 Response.

Findings identify the BAX-SOX9-CDK4 axis as an important mechanism contributing to the antitumor activity of CYD-4-61 and provide a strong preclinical rationale for its further development as a therapeutic strategy for aggressive GAC.

Gengyi Zou, Katsuhiro Yoshimura, Yibo Fan et al. · 0 citations
Jul 2026

Abstract B039: Genomic and epigenomic complexity underlies barrett’s esophagus progression to adenocarcinoma

This study defines the role of epigenetic reprogramming in BE-to-EAC progression by integrating spatial transcriptomics, single-cell analyses, and functional modeling, and demonstrates that enhancer activation correlates with transitions from stable epithelial identity to highly plastic, dysplastic, and malignant phenotypes.

Shilpa S. Dhar, J. Ajani · 0 citations

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