Shih-Hsin Tu

Engineered α9-nAChR-targeting antibodies attenuate nicotine-enhanced triple-negative breast cancer progression and exhibit favorable short-term tolerability in cynomolgus macaques.

Cigarette smoking and nicotine exposure promote breast cancer progression and poor outcomes by aberrantly activating nicotinic acetylcholine receptors (nAChRs), with α9-nAChR serving as a key oncogenic driver, especially in triple-negative breast cancer (TNBC). However, effective therapeutic strategies that directly ta...