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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Shifeng Chue

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Open access Sep 2026

The solid dispersion of a novel curcumin analogue (CACN136) prepared using PVP/Mannitol composite carrier significantly improved oral bioavailability and depression-like behavior in mice.

OBJECTIVE CACN136 is a novel curcumin analogue with antidepressant potential, but its poor aqueous solubility may restrict oral absorption. This study aimed to develop a rapidly dissolving solid dispersion of CACN136 (CACN136-SD) to further enhance its oral bioavailability and antidepressant efficacy. METHODS CACN136...

Yu-Meng Wei, Ke Gong, Rong-Zhu Li et al. · 0 citations

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