Author

Shiyong Zhang

3 papers indexed here

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Sep 2026

A Microenvironment-Adaptive Nanoadjuvant Resolves the Radioprotection and Radiosensitization Paradox in Cancer Therapy

The intrinsic spatiotemporal discord between augmenting tumor radiosensitivity and safeguarding normal tissue has persistently circumscribed the therapeutic horizon of radiotherapy. Here, we introduce a microenvironment-adaptive platform, cross-linked lipoic acid nanoadjuvant (cLAN), designed to strategically navigat...

Hao Guo, Zhong Shao, Ke Li et al. · ACS Nano · 0 citations

Open access Aug 2026

Poly (Lipoic Acid) Nanoparticles With High Blood-Brain Barrier Permeability and Enhanced Anti-Ferroptotic Activity for Ischemic Stroke Treatment.

Lipoic acid (LA) scavenges free radicals and was clinically tested for ischemic stroke. However, the short half-life and weak efficacy in penetrating the blood-brain barrier (BBB) limit its use in the brain. Here, we developed poly (lipoic acid) nanoparticles (pLANs) with a half-life of more than 15 h and a high effici...

Qing-Zhang Tuo, Juan Tan, Hong-Fa Yan et al. · Small · 0 citations

Jul 2026

Cross-Linked Diselenide Nanovesicles against Acute Liver Injury by Seamless Integration of ROS Elimination and Source Inhibition.

This work introduces a cross-linked diselenide nanovesicles with surface folic acid modification (FA@cSeLAV), which effectively targets hepatic macrophages, key mediators of ROS-driven damage in ALI, and seamlessly integrates symptomatic-level ROS elimination with the inhibition of endogenous ROS production.

Shao-Xiong Zhang, Donglin Wang, Qian Liu et al. · ACS Applied Materials and In... · 0 citations