Shi-Yi Wang

Host Protein Palmitoylation: A Two-Edged Sword in the Pathogenesis of COVID-19

Protein palmitoylation is a two-edged sword in regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. On the one hand, SARS-CoV-2 hijacks the host’s palmitoyl transferases (ZDHHC5/9/20) to modify its spike protein (S protein), enhancing its stability, membrane anchoring, and fusion, conseque...