Open access
Jul 2026
Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma.
A comprehensive single-cell atlas of the BrM TME is unveiled and a robust 12-gene BrM-informed prognostic signature for LUAD is established, validated across multiple LUAD survival cohorts.
Jing-Xiang Pang, Wentian Wu, Peiwen Zhu et al.
· Cancer Cell International · 0 citations