Shengmin Wu

Sub‑chronic dietary exposure to environmentally relevant doses of di‑(2‑ethylhexyl) adipate (DEHA) induces hepatic steatosis in female mice via disrupting the PPARγ pathway and inducing endoplasmic reticulum stress: In vivo and in vitro evidence.

It is demonstrated that environmental-level DEHA exposure promoted obesity and hepatic steatosis in female mice by disturbing the PPARγ signaling pathway and upregulating ER stress-related genes, highlighting a significant and previously underappreciated health risk of DEHA in females and calling for a reassessment of...