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Shengchun Wang

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Jul 2026

Directed Evolution of Nonheme Fe Enzymes for Enantioselective and Regiodivergent 1,3- and 1,4-Nitrogen Migration: Biocatalytic Asymmetric Synthesis of Noncanonical α- and β-Amino Acids.

Biocatalyst-controlled regioselective C(sp)-H functionalization of carboxylic acid derivatives provides a powerful method for the synthesis of noncanonical α- and β-amino acids. Herein, we report a nonheme Fe enzyme-catalyzed, regiodivergent, and enantioselective nitrogen migration, enabled by directed evolution of 1-a...

Huichong Liu, Liu-Peng Zhao, Shijia Li et al. · 0 citations

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