ABSTRACT Sevoflurane is one of the most commonly used general anesthetics in pediatric clinical practice worldwide. Although accumulating preclinical evidence indicates that neonatal sevoflurane exposure causes persistent cognitive impairments, the extracellular mechanisms remain unclear. Herein, we focus on perineuron...
Li-Rong Liang, Jia-Chen Wang, Tao-Zhi Wang et al.· Advancement of science· 0 citations
Pathogenic variants in MSL2, a core component of the histone-modifying MSL complex, are associated with neurodevelopmental disorders (NDDs) and white matter abnormalities; however, their mechanisms of pathogenicity remain unknown. In this study, we identified three patients with NDD carrying MSL2 variants, all of whom...
Jie Yuan, Yu-Hao Dong, Kai-Xiang Zhang et al.· Experimental and Molecular M...· 0 citations
ABSTRACT Aims The anterior cingulate cortex (ACC) is widely recognized as a key brain region in modulating itch and itch‐associated behaviors. Though neuronal mechanisms are increasingly clarified, the role of ACC astrocytes remains poorly understood. Methods By employing a diphenylcyclopropenone (DCP)‐induced chronic...
Ze Fan, Xiao-Tong Shi, You Wu et al.· CNS Neuroscience & Therapeut...· 0 citations
It is found that KD ameliorates social deficits and induces systemic ketosis with marked elevation of β-hydroxybutyrate (BHB) in KO mice, and HDAC9 is identified as a potential therapeutic target for ASD-related social deficits.
