Author

Shengping You

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#protein folding Sep 2026

Balanced regulation of UvsX activity and thermostability based on active learning.

A directed engineering strategy is employed combining energy-based screening and protein language models to obtain a triple mutant, TIG, which enhances residue flexibility and remodels the ATP-binding pocket, thereby improving DNA-binding pathway connectivity and strengthening the coupling between ATP hydrolysis and DN...

Ling-Song Li, Lin Zhang, Dong-Xia Li et al. · International Journal of Bio... · 0 citations

Jul 2026

Rational design of IsPETase variant toward efficient poly(ethylene terephthalate) ambient degradation.

The accumulation of poly(ethylene terephthalate) (PET) waste in the environment poses a severe ecological threat. While extensive research has focused on high-performance PET degradation by thermophilic enzymes, PET hydrolases are efficient under lower-temperature conditions, which would better align with green and ene...

Jiaxing Zhang, Yu Zhou, Baoyu Zhang et al. · Bioresource Technology · 0 citations