Author

Sheng-Nan Xia

3 papers indexed here

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Sep 2026

Isoschaftoside improves white matter injury via TREM2-mediated phagocytosis and anti-inflammatory effects.

BACKGROUND Ischemic white matter injury (WMI) is a core pathological mechanism underlying vascular cognitive impairment, for which effective clinical interventions are currently lacking. The natural flavonoid glycoside Isoschaftoside (ISO) has been reported to exhibit various pharmacological activities, but its effects...

Cheng-Gang Li, Yu-Hao Xu, Huai-Ping Tang et al. · International Immunopharmaco... · 0 citations

Aug 2026

Microglial RIOK3 promotes post-ischemic neuroinflammation by facilitating YBX1 phosphorylation and nuclear accumulation.

Excessive activation of microglia exacerbates secondary brain injury after ischemic stroke, yet the upstream mechanisms governing this response remain incompletely understood. This study aimed to investigate the role of RIO kinase 3 (RIOK3) in microglia-mediated neuroinflammation after ischemic stroke and to explore th...

Yang Geng, Ningning Zong, Chao Zhou et al. · Experimental Neurology · 0 citations

Open access Sep 2026

LILRB4 Attenuates Ischemic Brain Injury by Inhibiting Microglial Necroptosis via a RIPK3‐Dependent Mechanism

Microglia are central mediators of neuroinflammation following ischemic stroke. Our previous multi‐omics data revealed significant upregulation of leukocyte immunoglobulin‐like receptor subfamily B member 4 (LILRB4) in microglia after transient middle cerebral artery occlusion (tMCAO), but its functional role remains u...

Jing-Long Hu, Mei-Juan Zhang, Pin-Yi Liu et al. · Glia · 0 citations