Author

Sheng-Kai Hsu

3 papers indexed here

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#protein folding Open access Oct 2026

Evolutionary constraint on a core winter proteome across independently cold-adapted PACMAD grasses

Comparative proteomics tests whether protein-level cold responses show stronger cross-species conservation than previously observed at the transcript level, andStructural divergence of LEA3 in maize suggests that transcriptional induction alone does not ensure freezing tolerance; functional protection likely requires i...

Elad Oren, Jing-Jing Zhai, Travis E. Rooney et al. · PLoS ONE · 0 citations

#protein folding Open access Sep 2026

3D chromatin remodeling during domestication defines novel targets for crop improvement.

This study provides a resource for redefining precision-breeding paradigms by harnessing cryptic 3D chromatin targets by decoupling sequence-level from chromatin-level selection and shifting the subgenome expression balance of 39 homoeologs in cultivated cotton.

Xian-Hui Huang, Ya-Bing Peng, Xiu-Bao Hu et al. · Cell · 0 citations

Open access Aug 2026

PlantCAD2: A DNA foundation model for interpreting genomes across flowering plants

Summary Flowering plants (angiosperms) exhibit extraordinary species diversity, ∼200-fold variation in genome size, and relatively compact coding regions, presenting both a unique challenge and opportunity for DNA language models. Here, we introduce PlantCAD2, an extended-context, plant-specific DNA language model with...

Jing-Jing Zhai, Aaron Gokaslan, Sheng-Kai Hsu et al. · Cell Genomics · 1 citation