Oct 2026
NFAM1 organizes a lipid raft-restricted DAPP1-PLCG2 module to drive M2-like GAM polarization via Ca²⁺-NFAT1 signaling in glioma.
BACKGROUND Glioma-associated macrophages (GAMs) promote glioma progression, but the membrane-proximal mechanisms sustaining their tumor-supportive states remain poorly defined. METHODS Bulk and single-cell transcriptomic analyses, human glioma specimens, GAM models, and orthotopic glioma models were used to define th...
Yao-Chuan Zhang, Rong-Jin Chen, Yi-Fu Song et al.
· Neuro-Oncology · 0 citations