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Sheng-Cheng Shi

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Review Open access Aug 2026

The role of fumarate and itaconate in tumor microenvironment.

The oncogenic mechanisms of fumarate and itaconate are summarized, viable strategies to address technical hurdles in studying non-enzymatic protein modifications are proposed and new directions for the clinical treatment of tumors are offered through targeted inhibition of fumarate and itaconate.

Yi-Dan Fan, Han-Qiu Zhang, Jinkun Qin et al. · 0 citations

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