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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Shen-Yun Luo

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Open access Oct 2026

Sex hormone–binding globulin increases lumbar fracture risk via bone density, inflammation, and insulin pathways

Circulating sex hormone–binding globulin (SHBG) regulates bioavailable sex hormones that influence bone metabolism. We investigated whether genetically higher SHBG increases lumbar fracture (LF) risk and identified the biological pathways mediating this effect, including bone mineral density (BMD), C-reactive protein (...

Gu-Shang Xia, Rong Yang, Yu-Song Zhou et al. · 0 citations

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