Sep 2026
Super-enhancer–driven SGK1 activates polyamine metabolism to promote autoimmune uveitis
Uveitis, a leading cause of blindness, is driven by dysregulated immune responses, particularly autoreactive T cells. Despite advances in understanding its pathogenesis, key regulatory mechanisms remain elusive. Here, we integrate the cleavage under targets and tagmentation (CUT&Tag) and single-cell RNA sequencing (scR...
He Li, Lei Zhu, Zhao-Huai Li et al.
· Science Advances · 0 citations