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Shatakshi Shukla

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Open access Sep 2026

Matrix and intermembrane space-specific mitochondrial stress response in Alzheimer’s disease

Alzheimer’s disease (AD) lacks effective therapies, partly due to an incomplete understanding of mitochondrial dysfunction, a key driver of neurodegeneration. Mitochondria activate the unfolded protein response (UPRmt) to maintain proteostasis, but the roles of matrix- and intermembrane space (IMS)-associated stress re...

Shatakshi Shukla, Devin W. Kolmetzky, Shanikumar Goyani et al. · 0 citations

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