Ratiometric fluorescent pH probes typically rely on complex intramolecular energy/charge transfer, rendering the design strategies increasingly rigid. We report a conceptually distinct ratiometric probe based on pH-driven J-aggregate disassembly utilizing a spirocyclic BODIPY platform. Strategic installation of β-Cl...
Introduction Cisplatin (CIS)-induced nephrotoxicity is a dose-limiting adverse effect that hinders its clinical efficacy. Artesunate (ART) exerts well-documented anti-inflammatory and anti-oxidative effects, but its potential efficacy against CIS-induced nephrotoxicity remains poorly elucidated. Methods The renoprotect...
Hai-Feng Hu, Wen-Ting Zhang, Hui-Long Wang et al.· Frontiers in Pharmacology· 0 citations
Ischemia-reperfusion injury is a leading cause of acute kidney injury (AKI), which is characterized by high morbidity and mortality, as well as a substantial risk of progression to chronic kidney disease (CKD). Although supportive care has improved considerably, effective disease-modifying therapies are still lacking....
Yan Li, Wen-Ting Zhang, Sheng-Peng Zhang et al.· Frontiers in Pharmacology· 0 citations
Cyclophosphamide (CP) is a common alkylating anticancer drug. Artemisinin (ART), an antimalarial agent metabolized by hepatic CYP450s, exhibits promising antitumor activity. This study established a rapid and accurate LC-MS/MS method for the quantitative analysis of CP and its metabolite in mouse plasma, as well as to...
Huilong Wang, Wenting Zhang, Haifeng Hu et al.· Biomedical chromotography· 0 citations
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