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Author

Shaolei Geng

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Review Open access Aug 2026

Advancing recombinant protein production in CHO cells through metabolic engineering

Chinese hamster ovary (CHO) cells serve as the predominant platform for producing recombinant therapeutic proteins in biopharmaceutical manufacturing, the production capacity of which relies heavily on efficient protein synthesis, folding, and secretion pathways. However, during high-density and prolonged cultivation,...

Lu Hou, Weidong Li, Ziyan Li et al. · 0 citations
Open access Jul 2026

An enzyme-specific protein language model for catalytic property prediction

This manuscript introduces EnzGFM, an enzyme-specific hybrid model that improves both accuracy and efficiency across multiple prediction tasks and, together with the EnzGFM-Agent pipeline, demonstrates the ability to identify experimentally validated beneficial variants while reducing screening effort.

Chong Wang, Mengyao Li, Shaolei Geng et al. · 0 citations

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