Receptor-binding domain 2 of Clostridioides difficile binary toxin as a promising vaccine component against C. difficile infection
Symptoms of Clostridioides difficile infection (CDI) are primarily caused by two major protein toxins, toxin A (TcdA) and toxin B (TcdB). In addition, approximately 5-30% of C. difficile strains produce a third toxin, C. difficile binary toxin (CDT), which is has been associated with enhanced virulence and severe disea...