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Shao-Zhen Yan

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Open access Sep 2026

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully capture the dynamic pathological transit...

Dong Wang, Shao-Zhen Yan, Rong-Shen Zhou et al. · 0 citations
Open access Sep 2026

Cerebellar cortical amyloid deposition biases 18F-Florbetapir PET quantification with whole cerebellum as reference region.

Cerebellar cortical Aβ deposition raises WC reference signals and interferes with CL-based 18F-Florbetapir Aβ PET quantification, which systematically underestimates true cerebral Aβ burden.

Mei-Xin Wang, Sheng Bi, Han-Xiao Xue et al. · 0 citations

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