Shao-Hua Wu

Catalyst-controlled regiodivergence in enantioselective synthesis of spirocyclic γ- versus δ-lactams

We report a regiodivergent strategy for the catalytic asymmetric synthesis of enantioenriched spirocyclic γ- and δ-lactams from a single cyclic alkyne-tethered β-ketoamide precursor. Critically, simply switching the catalyst system between Cu(I)/Pyrabox and Ni(II)/Box enables precise toggling of the cyclization between...