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Author

Shaohua Qu

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Sep 2026

Exon 21 skipping in ARHGAP10: A splicing switch that governs breast cancer metastasis.

Rho GTPase-activating protein 10 (ARHGAP10) is recognized as a tumor suppressor, yet the functional impact of its alternative splicing isoforms on breast cancer metastasis remains unclear. This study aimed to elucidate the role and regulatory mechanism of ARHGAP10 exon 21 skipping in breast cancer progression. Our rese...

Zhi-Wei Wu, Meng-Zhen Huang, Liu Yu et al. · 0 citations
Jul 2026

HNRNPF-driven retention of exon 14 in HIF1A pre-mRNA promotes breast cancer metastasis.

The HNRNPF/HIF1A-L/CXCR4/AKT axis as a central regulatory circuit controlling breast cancer metastasis is elucidated and it is suggested that correcting the aberrant splicing of HIF1A may represent a novel therapeutic strategy for cancer.

Mengzhen Huang, Jiang Lei, Wei Wu et al. · 0 citations

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