Shao-Hua Ge

Engineered bacterial outer membrane vesicle vaccine prevents T cell exhaustion for antibacterial immunotherapy.

Gram-negative pathogens evade immune clearance and promote chronic infections by residing intracellularly. While outer membrane vesicles (OMVs) hold promise as antibacterial vaccine platforms, their clinical potential is limited by lysosomal entrapment of antigens and endotoxin-induced toxicity. Herein, we present an i...