Oct 2026
Alphitolic acid suppressed osteoclast differentiation via hindering Cox-2/NF-κB signal pathway and alleviated titanium particle-induced bone loss in vivo.
Total joint arthroplasty (TJA) effectively improves the quality of life for patients with end-stage joint disorders. However, aseptic loosening caused by titanium (Ti) wear debris-induced osteolysis remains the leading cause of implant failure and revision surgeries. In this study, we investigated the therapeutic poten...
Chun-Mei Xiu, Chi-Ting Yuan, Qiang Han et al.
· European Journal of Pharmaco... · 0 citations