Open access
Sep 2026
Microplastic exposure is associated with enhanced PI3K-Akt signaling in DSS-induced colitis: integrated bioinformatics analyses and in vivo validation
Background Microplastics (MPs) are widely distributed in the environment and may aggravate ulcerative colitis (UC), but the underlying molecular mechanisms remain unclear. Methods We integrated network toxicology, RNA-seq-based differential expression analysis, molecular docking, GeneMANIA-based functional association...
Li-Sha Lu, Yuan-Ming Yang, Shun-Yong He et al.
· Frontiers in Pharmacology · 0 citations