Open access
Oct 2026
Dual-stage inhibition of Plasmodium falciparum by a Skeletocutis-derived fungal metabolite targeting pyruvate kinase II
ABSTRACT Plasmodium falciparum resistance to current first-line treatments is threatening at-risk populations and underscores the urgent need for novel therapeutic targets and drugs. P. falciparum pyruvate kinases I and II are two essential enzymes with distinct roles and subcellular localizations within the parasite....
L. Hervé, N. Amanzougaghene, Séverine Amand et al.
· Antimicrobial Agents and Che... · 0 citations