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Shannen Grandy

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Open access Jul 2026

Inhibition of Pseudomonas aeruginosa-secreted protease IV reduces lung inflammation

PpL is established as a key virulence factor that triggers AP-1-mediated inflammatory signaling, structural and functional insights into PrpL inhibition are provided, and AprA is identified as a novel upstream PrpL activator, highlighting PrpL as a promising anti-virulence therapeutic target.

S. Daboor, Lauren D. Burton, Trilok Neupane et al. · 0 citations

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