Author

Shane R. Byrne

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Open access Aug 2026

Oncogenes have the most distinct codon biases in the genome and codon signatures that oppose tumor suppressor genes

Oncogenes and tumor-suppressor genes play opposing roles in cancer biology to promote and restrict growth, respectively. Codon usage patterns interface with tRNA modifications to control translation, leading to gene-specific codon signatures with regulatory potential. As such, codon-biased translational regulation has...

Chetna Mathur, Evan T. Davis, Dylan J. Ehrbar et al. · bioRxiv · 0 citations

#protein folding Sep 2026

Improving Yield and Assessing Quality of Secreted Proteins Over-Expressed in Pichia Pastoris with Chaperones and Structural Mass Spectrometry.

It is demonstrated that maximizing recombinant protein production requires optimization of both yield and structural quality and establish complementary strategies for improving secreted protein expression in Pichia.

Xin-Zhe Ren, E-Ming Rau, Lauren Coutu et al. · ACS Synthetic Biology · 0 citations