Author

Shanwen Chen

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Open access Sep 2026

Depleting luminal cysteine with engineered bacteroides vulgatus alleviates experimental colitis by suppressing Th17 differentiation through an ATF6-dependent mechanism

Ulcerative colitis (UC) is a chronic inflammatory bowel disease driven by dysregulated immune responses, particularly the aberrant activation of T helper 17 (Th17) cells. While microbiome-based therapies show promise, wild-type probiotics often lack specific mechanisms to target the metabolic and immunological drivers...

Jiang Wang, Zhe-Xian Tian, Shan-Wen Chen et al. · Inflammation Research · 0 citations

Open access Jul 2026

Decoding cancer circulating transcriptomic signatures with language models

GeneLLM is presented, a Transformer-based model that directly processes the nucleotide sequences of human-mapped cfRNA reads to identify cancer-indicative signatures and allows accurate cancer classification from plasma biopsies, suggesting that sequence-level modelling of plasma cfRNA can capture diagnostically releva...

Siwei Deng, Lei Sha, Yongcheng Jin et al. · Nature Communications · 0 citations