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Author

Shan-Shan Li

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Jul 2026

Pristimerin disrupts blood-testis barrier (BTB) integrity via ferroptosis and apoptosis by the NUR77/ATF3/CHOP pathway.

It is demonstrated that Pri directly targets NUR77, activating the NUR77-ATF3-CHOP axis and inducing both apoptosis and ferroptosis in Sertoli cells, leading to spermatogenesis dysfunction, thereby providing critical insights into Pri-induced testicular injury.

Jiaqi Li, Haoyu Chen, Zhengxin Lu et al. · 0 citations
Jul 2026

A methacrylated carboxymethyl chitosan hydrogel loaded with α-mangostin nano-micelle promotes infected diabetic wound healing involving PPAR-γ modulation.

An integrated approach combining network pharmacology, molecular docking, molecular dynamics simulations, and experimental validation revealed that the therapeutic efficacy of sustained local α-MG delivery involves the modulation of the PPAR-γ pathway.

Yuan Ma, Xu Liu, Zhewen Deng et al. · 0 citations

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