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Shan-Long Li

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#protein folding Open access Sep 2026

Intermediate-Resolution Modeling of Dynamic DNAs and Their Phase Separation

DNA is a fundamental biomolecule in eukaryotic cells, playing central roles in processes ranging from genome organization and transcription to innate immune signaling. Recent studies have revealed that DNA can undergo protein-free phase separation in the presence of divalent cations, yet the underlying molecular mechan...

Jessica Fong Ng, Shan-Long Li, Jian-Han Chen · bioRxiv · 0 citations

Open access Aug 2026

Antibiotic condensates activate magnesium signaling to drive drug tolerance

The spatial distribution of small molecules within cells shapes their biological activity, yet these distributions are generally assumed to be governed passively by reaction-driven electrochemical gradients. Here we show that aminoglycoside antibiotics actively control their own subcellular organization by undergoing p...

Yuefeng Ma, Wen Yu, E. Moon et al. · bioRxiv · 0 citations