Sep 2026
Structural basis for small-molecule agonism at GCGR and GIPR via a conserved intracellular allosteric site.
Findings reveal a conserved intracellular allosteric activation mechanism across multiple class B GPCRs and identify SIM1 and its analogs as valuable chemical tools for investigating receptor-specific intracellular allosteric regulation and G protein-preferential signaling.
Qian He, Shan Hong, Wen Hu et al.
· Acta Pharmacologica Sinica · 0 citations