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Sep 2026

Structural basis for small-molecule agonism at GCGR and GIPR via a conserved intracellular allosteric site.

Findings reveal a conserved intracellular allosteric activation mechanism across multiple class B GPCRs and identify SIM1 and its analogs as valuable chemical tools for investigating receptor-specific intracellular allosteric regulation and G protein-preferential signaling.

Qian He, Shan Hong, Wen Hu et al. · 0 citations

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