Open access
Aug 2026
Structure-conditioned self-supervised learning of residue interaction constraints in protein kinases for variant interpretation
A structure-based method using SE(3)-transformers to learn residue compatibility with the local structural environment from experimentally resolved kinase 3D structures that captures biologically meaningful relationships between residue identity and 3D structural context is presented.
Shakiba Fadaei, F. Krebs, V. Zoete
· Bioinformatics · 0 citations