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Author

Shajedul Islam

2 papers indexed here

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Open access Sep 2026

The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, yet their clinical impact is limited by immune-related adverse events (irAEs), therapeutic resistance, and the lack of reliable predictive biomarkers, contributing to a shift from early promise to a therapeutic plateau. irAEs affect multiple organ s...

Joud Hajjar, B. Stephen, A. Aaroe et al. · 1 citation
Open access Jul 2026

The CD83 axis between Tregs and CCR7+ dendritic cells governs anti-tumor immune responses 2309951

Immune checkpoint blockade (ICB) has advanced the treatment of melanoma and other cancer types. Despite its success, only about half of the treated patients respond, with many developing resistances. One contributing factor is the poor infiltration of effector T cells in the solid tumors, along with the immunosup...

Ruparoshni Jayabalan, Ricardo Gonzalez-Delgado, Luis A. Castillo Montanez et al. · 0 citations

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