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Author

Shailza Singh

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Review Open access Sep 2026

MicroRNA circuits and regulatory networks: emerging therapeutic paradigm

ABSTRACT MicroRNAs (miRNAs) are small non-coding RNAs whose function is to regulate gene expression post-transcriptionally. Transcription factors (TFs) are the DNA-binding proteins responsible for activation or repression of a gene. Together, miRNAs and TFs form regulatory networks that modulate cellular homeostasis. I...

Swati Goswami, Shailza Singh · 0 citations
Open access Aug 2026

IL-6 signaling orchestrates proteolytic hubs MuRF1 and Atrogin-1 in NSCLC induced sarcopenia

A systems-level framework is provided that transforms broad observations of inflammation into ranked therapeutic targets and support combined strategies aimed at blocking the IL-6/STAT3–myostatin/SMAD–FOXO1/3–MuRF1/Atrogin-1 axis to mitigate NSCLC-associated sarcopenia.

Gautam Kumar, Shailza Singh · 0 citations

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