Background The quality of cavity preparation critically influences the longevity and success of restorative dental treatments. Current assessment methods remain largely subjective, relying on visual inspection and examiner judgment, which are prone to variability and limited reproducibility. Although three-dimensional (3D) imaging enables quantitative evaluation, its routine use in clinical and educational settings is limited by cost, accessibility, and workflow complexity. Objective This study aimed to develop an automated, objective, and clinically interpretable framework for evaluating dental cavity preparation quality using standard two-dimensional (2D) images, with optional integration of 3D depth information. Methods A deep learning pipeline based on enhanced U-Net architectures was developed to automatically segment cavity and cusp regions from 2D molar photographs. Anatomically informed geometric analyses were applied to quantify cavity-shape similarity, intercuspal distance, isthmus width, and cavity proportionality. Global cavity-shape conformity was assessed using Elliptic Fourier Descriptors (EFDs), enabling scale-, rotation-, and translation-invariant comparisons with reference preparations. When 3D STL data were available, cavity depth and cavity-bed smoothness were additionally quantified. These measurements were integrated into a transparent Cavity Quality Score (CQS) ranging from 1 to 10. Results The cavity segmentation model achieved an internal validation Dice coefficient of 0.81 and an Intersection-over-Union of 0.74, while cusp segmentation achieved a Dice coefficient of 0.83. External validation using measurements from three independent experts demonstrated close agreement between automated predictions and expert consensus for EFD cavity-shape similarity (MAE = 1.32 percentage points; r = 0.981), pooled isthmus-width measurements (MAE = 0.03 mm; r = 0.995), pooled cusp-pair distances (MAE = 0.08 mm; r = 0.999), and cavity depth estimation (absolute error ≈ 0.01 mm). Conclusion This study presents a hybrid, explainable artificial intelligence framework for objective assessment of dental cavity preparation using widely available 2D images. By integrating deep learning with anatomically informed geometric analysis, the proposed CQS offers a transparent and scalable tool for formative feedback in clinical and competency-based dental education. Further validation against expert summative grading is required before high-stakes implementation.
Abdullah F Alshammari, B. A. Anazi, M. Khan et al.· Frontiers in Artificial Inte...· 0 citations
Epigenetic modifications play a crucial role in cancer, influencing cellular physiology, extracellular matrix (ECM) remodeling, and immune responses. With growing emphasis on chromatin remodeling and the epigenetic regulation of immunity, these regulatory pathways and related players have become focal points of oncological investigations. Epigenetic manipulation of immune system components has emerged as a promising strategy in cancer treatment. Several FDA-approved "epi-drugs" target the epigenome to modulate immune responses and offer new opportunities across different cancers. DNA repair pathways contribute significantly to the avoidance of cancer initiation and also contribute to cellular resistance in cancer treatment. Chromatin remodelers such as INO80, Fun30, and RAD54 play essential roles in DNA damage response (DDR) through homologous recombination and non-homologous end-joining pathways, and their dysregulation leads to genome instability and tumor progression. Chromatin remodeling complexes, including SWI/SNF and CHD families, are frequently altered across various cancer types, further highlighting their role in cancer pathophysiology. Targeting these chromatin modifiers and associated DNA repair mechanisms may provide novel therapeutic options. In addition, combining epigenetic modulators with immunotherapies has shown promise in enhancing responses to immune checkpoint blockade. Epigenetic drugs such as histone deacetylase (HDAC) inhibitors and DNA methylation inhibitors are being explored for their synergistic effects with immunotherapy. While the interplay between chromatin remodeling, DNA repair, and immune responses provides a strong framework for developing targeted oncological strategies, further research is required to better understand these interactions and optimize their clinical application.
S. Riaz, Mehwish Iqbal, Farwa Tahir et al.· Molecular Medicine· 0 citations
The pharmacophore-based screening and docking analysis identified eleven promising EGFR-binding compounds, of which eight demonstrated optimal ADMET characteristics and stable interactions within the active site during molecular dynamics simulations, suggesting their potential efficacy as EGFR inhibitors.
M. Moulay, M. Mahmoud, Reem M. Farsi et al.· Journal of King Saud Univers...· 0 citations
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