Author

Shafagh A. Waters

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Open access Sep 2026

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit exceptionally well whilst limiting severe lung disease. Here, we demonstrate that this phenotype has evolved through two temporal...

A. Aggarwal, S. Ognenovska, Timothy Ison et al. · bioRxiv · 0 citations

Open access Aug 2026

Phage-encoded sRNA counteracts xenogeneic silencing in pathogenic E. coli

A prophage-encoded small RNA, HnrS, is identified that functions as an anti-silencing factor by targeting the H-NS paralogue Hha, thereby modulating Hha–H-NS repression of virulence loci including the LEE type III secretion system.

Pranita Poudyal, Brandon M. Sy, Daniel G. Mediati et al. · PLoS Pathogens · 0 citations

Review Open access Aug 2026

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

It is proposed that CF may provide a naturally occurring human context in which chronic epithelial stress sustains EMP‐like pressure, a concept that requires direct validation in human CF intestinal tissue.

B. Umashankar, Ines Pankonien, Margarida D. Amaral et al. · Cell Proliferation · 0 citations