Open access
Aug 2026
Integrative single-cell eQTL and GWAS analyses identify cell-type-specific regulatory mechanisms underlying ESCC susceptibility.
A cell-type-resolved regulatory framework for interpreting inherited susceptibility in esophageal squamous cell carcinoma is established and RPS3A is prioritized as a susceptibility gene whose genetically regulated expression colocalizes with ESCC risk variants and increases during malignant progression.
Lina Song, Miao-Xin Pan, Yue-Ping Li et al.
· Cell Reports · 1 citation