Review
Open access
Oct 2026
How do low-complexity domain interactions control transcription?
Abstract A substantial portion of the proteome consists of intrinsically disordered regions (IDRs) that do not fold into well-defined structures. IDRs often comprise low-complexity domains (LCDs), whose repetitive, compositionally biased sequences drive multivalent interactions that can lead to liquid–liquid phase sepa...
Jia-Min Guo, Qin-Yu Han, Kyogo Nagashima et al.
· Biochemical Society Transact... · 0 citations