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Seyede Helma Naseri Sadr

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Review Open access Oct 2026

Noradrenergic gain failure and cognitive-state instability in aging and Alzheimer's disease

This hypothesis-driven narrative review integrates adaptive gain theory, locus coeruleus–norepinephrine (LC–NE) anatomy and pathology, LC-sensitive MRI, pupillometry, EEG/fMRI state dynamics, sleep research, behavioral variability, and Alzheimer's disease biomarkers to examine how disease-related vulnerability becomes...

Seyed Kiarash Sadat Rafiei, Mahsa Faramin Lashkarian, Seyede Helma Naseri Sadr et al. · 0 citations

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