Aurone Derivatives as Inhibitors of ERK Phosphorylation in HCC827 Non-Small Cell Lung Cancer Cells.
This study identifies d4 as a promising lead compound that targets ERK-mediated signaling in HCC827 NSCLC cells and highlights the therapeutic potential of the (Z)-2-benzylidenebenzofuran-3(2H)-one structure in inhibiting hyperactivated MAPK signaling.