Targeted integration of miR-17 using CRIS-PITCh/RMCE hybrid system in CHO cells is associated with increased recombinant ACE2 production
Chinese hamster ovary (CHO) cells are widely used for recombinant therapeutic protein production. MicroRNA engineering represents a potential strategy for improving CHO cell performance; however, conventional random integration can introduce variability in transgene expression. Here, we investigated targeted miR-17 int...
Setare Adibzadeh, Elham Bayat, Samira Komijani et al.
· BMC Biotechnology · 0 citations