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Author

Sepehr Nematollahzadeh

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Open access Sep 2026

Alternative bipartite arrangements of VP1 BR1-3 drive efficient nuclear import of AAV2 capsids.

Adeno-associated viruses (AAVs) are among the most extensively studied viral gene-therapy vectors, yet the mechanisms governing their nuclear entry remain incompletely understood. Efficient transduction requires that the AAV capsid, or its structural subunit VP1, traverse the nuclear envelope to deliver the therapeutic...

M. Hoad, Sepehr Nematollahzadeh, Davide Cimichella et al. · 0 citations

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