Seong Gi Lim

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

A synthetic ionizable lipid with a dual pKa property that is retained in formulated LNPs is introduced and it is shown that after intravenous injection, these dual pKa LNPs produce lung‐selective mRNA expression with higher potency than a cationic lipid‐rich comparator while remaining well tolerated.