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Author

Seon-Jeong Kim

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Aug 2026

Polyaspartamide-Mediated Messenger RNA Delivery Enables Efficient Ex Vivo Engineering of Chimeric Antigen Receptor Natural Killer Cells via Enhanced Cellular Internalization.

Engineered natural killer (NK) cells expressing chimeric antigen receptor (CAR) represent a promising alternative to CAR T-cell therapy due to their allogeneic potential. However, current CAR NK cell production relies on lentiviral or retroviral transduction to achieve stable CAR expression, requiring complex, multiste...

Ha Yeon Park, Seon-Jeong Kim, Kyuree Kim et al. · 0 citations
Sep 2026

Programmable ternary polyplexes redirect systemic mRNA delivery to the spleen for in vivo CAR engineering.

In vivo engineering of chimeric antigen receptor (CAR) immune cells has emerged as a promising alternative to ex vivo cell manufacturing, but its clinical translation remains limited by the lack of delivery systems capable of selective programming immune cells within lymphoid organs. Here we report a rationally enginee...

Sung Been Lim, Seon-Jeong Kim, Jun-Su An et al. · 0 citations

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