Parenteral vaccines against respiratory viruses poorly block infection and transmission due to suboptimal induction of mucosal immunity. In contrast, hybrid immunity and heterologous-route immunization regimens generate protective mucosal and systemic immunity. Herein, we examine how chronological order in heterologous...
Matthew J. Wiest, Gabriel Laghlali, Julianne d'Acunzo et al.· EMBO Molecular Medicine· 0 citations
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease caused by the tick-borne bunyavirus SFTSV. SFTSV is primarily transmitted by Haemaphysalis longicornis ticks and can cause a hemorrhagic fever-like illness characterized by high fever, thrombocytopenia, leukopenia, and multiorgan failure...
J. Levican, Natalia Ferressini Gerpe, Seok-Chan Park et al.· bioRxiv· 0 citations
Influenza virus infects the respiratory mucosa, highlighting the importance of mucosal immunity for early protection and transmission control. Here, we evaluated whether intranasal (IN) vaccination with recombinant trimeric hemagglutinin protein from A/Michigan/45/2015 (triHA) formulated with a combined mucosal adjuvan...
V. Yan, Seok-Chan Park, Matthew J. Wiest et al.· bioRxiv· 0 citations
It is demonstrated that vaccination through different routes (mucosal vs. systemic) differentially harnesses trained immune responses established by prior viral respiratory infection and alters the local inflammatory cell composition and subsequently alters the Th and mucosal antibody response induced by immunization.
Matthew J. Wiest, James R. Baker, Chun Chen et al.· Journal of Immunology· 0 citations
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