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Open access Sep 2026

Structure and function of TM6SF1 reveals role in mTORC1 signaling.

The transmembrane 6 superfamily (TM6SF) comprises two members: TM6SF1, a ubiquitously expressed lysosomal membrane protein of unknown function, and TM6SF2, an endoplasmic reticulum protein required for bulk lipidation of Apolipoprotein B-containing lipoproteins. Here, we used cryo-electron microscopy (cryo-EM) to deter...

Sen Hong, Liang-Jie Jia, Rong Wang et al. · 1 citation

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