Oct 2026
Monofluoromethylphenylalanine: A Sensitive 19F Probe for Protein Conformational Dynamics In Vitro and in Cells
The combination of site-specific incorporation of 19F-labeled unnatural amino acids (UAAs) and 19F nuclear magnetic resonance (NMR) spectroscopy is a powerful strategy for investigating protein structure, dynamics, and interactions. However, commonly used 19F-containing UAAs often suffer from narrow chemical shift di...
Pan Shi, Jun Liang, Xiao-Li Liu et al.
· Journal of the American Chem... · 0 citations