Aug 2026
HighMorph: De Novo Cyclic Peptide Sequence Design via Protein-Protein Interaction Recapitulation.
HighMorph is presented, an interaction-guided framework that combines protein–protein interaction information with artificial intelligence for rational cyclic peptide design and provides insights for developing therapeutics targeting challenging protein interfaces.
M. Lan, Chengyun Zhang, Wentong Wang et al.
· Journal of Medicinal Chemist... · 0 citations